HORDB

ID: hor001686
Uniprot ID: P19802
Protein name: PN
Gene name: NA
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: FARP (FMRFamide related peptide) family
Source: animal
Expression: Expressed in 280 cells of the CNS including the EGP heart excitatory motoneurons.
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0007218 neuropeptide signaling pathway
GO CC: GO:0005576 extracellular region

Sequence: SEQPDVDDYLRDVVLQSEEPLY
Length: 22(82-103)
Propeptide: MKTWSHVALLACLSIKWLTCVMADSIYCDDPDMCSMTKRFLRFGRALDTTDPFIRLRRQFYRIGRGGYQPYQDKRFLRFGRSEQPDVDDYLRDVVLQSEEPLYRKRRSTEAGGQSEEMTHRTARSAPEPAAENREIMKRETGAEDLDEEKRFMRFGRGDEEAEKRFMRFGKSFMRFGRDMSDVDKRFMRFGKRFMRFGREPGTDKRFMRFGREPGADKRFMRFGKSFDGEEENDDDLYYNESDADSNDDVDKRFM
Signal peptide: MKTWSHVALLACLSIKWLTCVMADSIYCDDPDMCS
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Induces contractions in visceral and somatic musculature as well as in the heart. May play a role as cotransmitters or modulators in a number of significant neuronal systems
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-P01048-F1.pdb

hor001686_AF2.pdb

hor001686_ESM.pdb

Mass:	298454	Formula:	C114H173N27O43
Absent amino acids:	ACFGHIKMNTW	Common amino acids:	D
pI:	3.45	Basic residues:	1
Polar residues:	4	Hydrophobic residues:	6
Hydrophobicity:	-88.18	Boman Index:	-6151
Half-Life:	1.9 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	92.73
Instability Index:	10142.27	Extinction Coefficient cystines:	2980
Absorbance 280nm:	141.9

PubMed ID: 7904219
Title: Processing of the FMRFamide precursor protein in the snail Lymnaea stagnalis: characterization and neuronal localization of a novel peptide, 'SEEPLY'.